DOI: https://doi.org/10.36347/sjmcr.2025.v13i11.058

Pages: 2900-2901

Priapism is a painful and prolonged erection (lasting more than 4 hours) occurring in the absence of sexual stimulation. This condition requires emergency intervention to prevent irreversible damage to the corpora cavernosa. Approximately half of drug-induced priapism cases are associated with antipsychotics, particularly those with a high affinity for alpha-1 adrenergic receptors. We report the case of a patient taking risperidone who experienced ischemic priapism. Through this clinical case and in light of recent publications, we discuss, firstly, the pathophysiological mechanisms, risk factors, and therapeutic options for this condition, and secondly, some practical recommendations to prevent the occurrence of neuroleptic-induced priapism.