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Scholars Journal of Applied Medical Sciences | Volume-7 | Issue 04
A Comparative Study of Efficacy and Safety of Ondansetron versus Palonosetron for the Treatment of Post-Operative Nausea and Vomiting
Dr. Wali Mohommad Momin, Dr. Tanveer Ahmad Khan, Dr. Vali Basha
Published: April 30, 2019 | 174 71
DOI: 10.36347/sjams.2019.v07i04.006
Pages: 1393-1397
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Abstract
The management of Post-operative Nausea and vomiting is an important consideration in surgical procedures. Inadequately treated PONV may result in prolonged post-operative care and increase the burden of treatment. We in the present study tried to evaluate the safety and efficacy of Ondansetron versus Palonosetron for the treatment of Post-Operative Nausea and Vomiting in elective surgical procedures. Methods: This cross sectional prospective study was conducted in the Department of Pharmacology, and Department of ENT, Government Medical College and Hospital, Rajnandgoan, CG. A total of n=79 were selected based on the inclusion and exclusion criteria. They were divided in two groups viz Group I (Ondansetron) n=40 and Group II (Palonosetron) and n=39. The Ondansetron Group (I) received Ondansetron 8mg IV in 10 ml normal saline over 30 seconds immediately before induction of general anesthesia and group (II) received inj. Palonosetron were given by 0.075mg IV. A standard anesthesia technique was followed endotracheal intubation was done with appropriate size cuffed endotracheal tube. In the monitoring room all the patients’ recovery parameters were checked and any episode of nausea or vomiting (PONV) was recorded at an interval of 30 min, 2 hours, 6 hours and 24 hours. Frequencies of rescue medication given were noted. Results: In the group I 32 (80%) were belonging to ASA Grade I and 8(20%) belonging to ASA Grade II. In the group I the 26(66.66%) of patients with score 2 similarly in the Group II 22(55%) were with Apfel score 2. In the group I a total of n=13 patients were seen with nausea and in Group II n=7 patients were with nausea. The p values for the postoperative nausea between two groups were found to be <0.05 which is significant. The incidence of postoperative vomiting in group I was seen in 10(25%) out of the total 40 patients and most of the patients had vomiting between 6 -24 hours 6 (15%) had vomiting and 2(5.0%) between 0 – 2 hours and 2 – 6 hours. I