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Scholars Academic Journal of Pharmacy | Volume-3 | Issue-02
In-Vivo anthelmintic Activities of Ethanol Extract of Croton (Codiaeum variegatum L. Blume) Against Tapeworm Hymenolepis microstoma
Gofarana Wilar, Sri Agung Fitri Kusuma, Yusuf Ridwan, Fairuz Amni
Published: Feb. 28, 2014 | 132 104
DOI: 10.36347/sajp
Pages: 108-115
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Abstract
As per reported in a previous study, the extract of the croton twig possesses an anthelmintic activity against the Hymenolepis spp cestode in an in Vitro model. The aim of the present study was to determine the anthelmintic activity of the croton twig extract against the tapeworm Hymenolepis microstoma in Vivo. The study was started out by experimentally infecting mice with H. microstoma. Infected mice were divided into five groups consisting of one control negative group, one control positive group, and three test groups of three different doses; 125, 250, and 500 mg/kg BW. Evaluation was carried out by the fecal egg count reduction (%FECR) and the worm count reduction. Statistical analysis showed that all test group have lower egg per gram count and lower worm count than that of the control negative group. Result showed at dose 125 mg/kg BW, the croton twig extract has the highest ability to reduce the number of eggs with an %FECR of 63,25%, whilst the highest ability of reducing the number of worms was shown by the extract at dose 500 mg/kg with a %WCR of 63%.It is suggested that further works including safety, effective dose need to be carried out before using twigs C.variegatum as anthelmintic agent.