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Scholars Academic Journal of Pharmacy | Volume-3 | Issue-02
Synthesis, Characterization and Evaluation of Anticonvulsant activity of some Novel 4-Thiazolidinone Derivatives
Asish Bhaumik, M. Ashok Chandra, Shubhankar Saha, Juturu Mastanaiah, Telu Visalakshi
Published: Feb. 28, 2014 | 139 138
DOI: 10.36347/sajp
Pages: 128-132
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Abstract
The objective of the present work is the synthesis of N-[2-(4-substituted phenyl)-4-oxo-1,3-thiazolidine-3-yl]- 2-(naphthalene-2-yloxy)acetamide and evaluation of anticonvulsant activity. Based on this a new series of compound have been planned to synthesize by reacting β-napthol,ethyl chloroacetate, hydrazinemonohydrate, ethyl alcohol and various aromatic aldehydes. The anticonvulsant activity of the test drugs were evaluated by using MES induced convulsions in mice. The percentage protection was estimated by observing the number of animals showing abolition of Hind Limb Tonic Extension (HLTE) or extension not greater than 90o. The synthetic derivatives (A9,A8,A2,A1&A10) 200 mg/kg have shown 95.85%, 90.04% ,84.23%, 79.75% & 73.44% protection against MES induced seizure respectively.