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Scholars Academic Journal of Pharmacy | Volume-3 | Issue-02
Study of Influence of Povidone and Sodium Lauryl Sulphate on Performance of Mouth Dissolving Tablets of Mirtazapine
Grandhi Srikar, G. Kavitha, A. Sai Sirisha
Published: Feb. 28, 2014 | 138 295
DOI: 10.36347/sajp
Pages: 201-207
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Abstract
Mouth dissolving tablets disintegrate and/or dissolve in saliva immediately when they are placed in mouth. Their rate of disintegration and dissolution are highly influenced by the formulation and method of manufacture. In the present investigation, it was aimed to study the influence of two hydrophilic excipients viz. povidone (PVP) and sodium lauryl sulphate (SLS) on the performance of mouth dissolving tablets of mirtazapine prepared by direct compression technique. Super – disintegrants are commonly employed in mouth dissolving tablets to enhance disintegration and dissolution rates. Still higher dissolution rates might be achieved if all the formulation contains hydrophilic excipients even lubricants also. In the present work, 9 different formulations were prepared using three super – disintegrants viz. sodium starch glycolate, crospovidone and cross carmellose sodium containing alone, and combination of PVP and SLS with each disintegrant. The disintegration and dissolution tests revealed interesting findings on behavior of SLS that though it increased disintegration time, it enhanced dissolution rate. The PVP was found to be effective as binder even in dry form.