DOI: 10.36347/sajp

Pages: 83-86

Rapid, specific and economic UV spectrophotometric method has been developed to determine the methoxsalen content in bulk and pharmaceutical dosage formulations. At a pre-determined λ max of 247nm,it was proved linear in the range of 1.0–12.0 mg/mL, and exhibited good correlation coefficient (R2-0.999 .This method was successfully applied to the determination of methoxsalen content in marketed brand(Melanocyl R2-0.982, Meladerm R2- 0.971) and the results were in good agreement with the label claims. Methoxsalen is a photosensitizing agent which has a chemical structure susceptible to degradation. The obtained results proved that the method can be employed for the routine analysis of methoxsalen in bulks as well as in the commercial formulations.