DOI: 10.21276/sajp.2018.7.3.5

Pages: 134-138

Dementia is a syndrome of gradual onset and continuous decline of higher cognitive function. By 2050, more than 115 million people will have dementia. The prevalence of dementia rapidly increases from about 2-3% among those aged 70–75 years to 20–25% among those aged 85 years or more. Etiology of dementia is Alzheimer’s disease (AD), vascular dementia, and other neurodegenerative disease. Discovery of complete Renin angiotensin system (RAS) in the brain, and Potential function of Ang II in the etiology of certain neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, seizures, and the development of metabolic syndrome and diabetes. Telmisartanpossess partial peroxisome proliferators’ activator receptor gamma (PPAR) agonistic activity. PPAR-γ agonists have been reported to effectively attenuate oxidative stress, inflammation and apoptosis in the central nervous system (CNS). Wister albino rats weighing between 150-250 grams were taken for the present study. Rats were divided in five different groups,