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Scholars Academic Journal of Pharmacy | Volume-8 | Issue-03
Appraisal of in vitro Antioxidant and in vivo Anti-Inflammatory Activities of Various Extracts from the Fruits of Vitis vinifera L
Deepak Kumar Jain, Amit Nayak, Preeti Patel, Saurabh Jain, Mohammad Azaz Khan
Published: March 30, 2019 | 125 90
DOI: 10.21276/sajp.2019.8.3.4
Pages: 86-93
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Abstract
The objective of the present study is to evaluate in vitro antioxidant and in vivo anti-inflammatory activities of various extracts from the fruits of vitis vinifera L. Grapes (Vitis vinifera) are universally appreciated fruit for their delicacy, nutrition and accepted as functional food. The dietary consumption of grape and its products is connected with a lower incidence of degenerative diseases such as cardiovascular disease and certain types of cancers. Most recent interest has focused on the bioactive phenolic compounds in grape. Flavanols, Anthocyanins and resveratrol are the most important grape polyphenols because they possess many biological activities such as anticancer, anti-inflammation, antiaging antioxidant, cardioprotective and antimicrobial properties. Qualitative and quantitative phytochemical screening of methanolic and ethanolic extract was carried out to identify the phytoconstituents. The In vitro antioxidant activity of methanolic and ethanolic extracts of Vitis vinifera was assessed against DPPH radical scavenging activity, reducing power assay using standard protocols. The anti-inflammatory activity was evaluated using carrageenan induced paw edema method on wistar albino rats. Methanolic extracts (200 and 400 mg/kg) showed significant and dose-dependent anti-inflammatory effects. Methanolic extract showed higher antioxidant activity than ethanolic extracts. It can be concluded that antioxidant and inflammatory efficacy of Vitis vinifera might be due to presence of antioxidant property and active phytoconstituents.