DOI: 10.21276/sajp.2019.8.8.6

Pages: 421-423

Aim of present study was to investigate the effects of Solanum xanthocarpum Schrad and wendl on degranulation of mast cells in abdominal mesentery of male albimo rats. 4 groups of animals (6 animals per group) were used. All animals except group I were sensitized and challenged with ovalbumin (40 mg/rat) followed by treatment with standard dexamethasone or S. xanthocarpum ethanolic whole plant extract (0.5 mg/kg b.wt) (SXE). %Protection offered by drugs against mast cell degranulation was studied in isolated mesentery stained with toluidine blue. Number of mast cells with extruded granules and entact cells were counted under microscope (x45). Allergen treatment resulted in significant increase in number of degranulated mast cells compared to normal control group. After treatment with SXE for 28 days significant decrease (55±4.22%) in number of mast cell with extruded granules compared to ovalbumin control group were found. However, the effects were not found to be significant in animals treated with standard dexamethasone compared to ovalbumin control group. Results of study show powerful mast cell stabilizing property of S. xanthocarpum ethanolic whole plant extract.