DOI: 10.36347/sajp.2020.v09i01.006

Pages: 23-31

Thiazolidinediones (TZDs) constitute an important class of heterocyclic compounds which possess significant antitubercular activity along with various other activities like antimicrobial, anti-HIV, anti-inflammatory, antioxidant and anticonvulsant. Tuberculosis is serious health complication in which multidrug-resistance is challenging problem in treatment of tuberculosis. In the proposed article, we have shown new methods of synthesis of thiazolidinediones and antitubercular activity of the synthesized compounds. Various substituents (electron donating as well as withdrawing) like –methoxy, -chloro, -flouro, -nitro, -hydroxy are attached at different positions on different aliphatic and aromatic substitutions of thiazolidinedione ring amongst them, the compounds possessing electron withdrawing groups on substitutions have shown enhancement in the antitubercular activity.