DOI: 10.36347/sajp.2020.v09i09.002

Pages: 257-262

Preformulation study is a part which is initiated formerly the new molecule is seeded. In a broader way, it pact with studies of physical, chemical, analytical, and pharmaceutical properties related to molecule and provides idea about suitable modification in molecule to show a better performance. Preformulation parameters study can be linked to production of effective, safer, stable, and reliable pharmaceutical formulation. Tramadol is an opioid pain medication used to treat moderate to moderately severe pain. The mechanism of action is not clear, even though the parent and metabolite of Tramadol binds to μ-opioid receptors and results in weak inhibition and reuptake of nor-epinephrine and serotonin. In the present works generally goal of preformulation studies of Tramadol HCl is to engender information useful in developing stable and Bioavailable dosage forms.