DOI: 10.36347/sasjs.2024.v10i03.022

Pages: 387-393

Context: Antibiotic prophylaxis is provided when an infection is not present but the chance of postoperative infection is high. Antibiotic prophylaxis prevents surgical site infections (SSI). Improper prophylaxis involves unnecessary and prolonged use of broad-spectrum antibiotics. Regrettably, most of our centers follow this pattern. This study compares the use of recommended and improper antibiotic prophylaxis in clean-contaminated surgery to advocate and encourage its use. Objectives: To see the outcome of short-term prophylactic antibiotics in comparison to prolonged traditional use of antibiotics. Also aimed to identify a proper schedule for prophylaxis, thus reducing costs, side effects and incidence of drug resistance. Materials and Method: This prospective study was conducted during the period from June 2021 to May 2022 in different surgical units of Sher-E-Bangla Medical College Hospital (SBMCH), Barisal. In this study, 150 patients were selected randomly irrespective of sex who underwent most commonly done clean-contaminated surgery like Appendicectomy for acute or recurrent Appendicitis, Herniotomy and Herniorrhaphy for Obstructed Inguinal Hernia, Open or Laparoscopic Cholecystectomy for Cholelithiasis, Palliative Gastrojejunostomy for Carcinoma Stomach (advanced case) and Choledocholithotomy for Choledocholithiasis. Half of them (group A) received short-term prophylactic antibiotics and another half (group B) received traditional long-term antibiotics. The antibiotic selection, its doses and timing of administration in both groups were selected as per guidelines (study protocol) i.e.; group A - only three doses and group B - traditional prolonged doses. Both groups were followed up at different time periods (POD) and noted their complaints and findings if any in a tabulated form. Result: It was found that postoperative SSI rate was 6.67% and 8% in the short-term prophylactic and long-term traditional group respectively. Among the infected patient .......