DOI: https://doi.org/10.36347/sjmcr.2025.v13i04.043

Pages: 754-757

Sjögren’s syndrome (SS) is an autoimmune disorder that often presents with neuropsychiatric manifestations, either at the onset or during the course of the disease. Psychiatric symptoms such as depression, anxiety, and cognitive dysfunction are common in SS. However, bipolar disorder (BD), characterized by alternating periods of mania and depression, is a rare and under-documented complication of SS. Recent studies suggest a possible connection between autoimmune diseases, including SS, and an increased risk of developing BD, although this relationship remains poorly understood. This case report presents a 62-year-old woman diagnosed with SS who developed a manic episode after starting corticosteroid and immunosuppressant therapy.