DOI: https://doi.org/10.36347/sajb.2025.v13i05.010

Pages: 569-573

Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder that impacts many women of reproductive age, marked by symptoms like irregular menstrual cycles, infertility, hirsutism, and metabolic issues such as insulin resistance [1-3]. Recent studies have shed light on the impact of gut microbiota—the intricate community of microorganisms living in the gastrointestinal tract—on the pathophysiology of PCOS. Dysbiosis, which refers to an imbalance in gut bacteria, has been connected to the worsening of PCOS symptoms and related metabolic disorders. This connection raises significant questions about the potential effectiveness of microbiota-targeted interventions in managing the syndrome. [4][5]. Research indicates that women with PCOS show a decrease in gut microbiota diversity and changes in bacterial composition when compared to healthy individuals. This alteration may play a role in heightened insulin resistance and chronic inflammation, which are two primary characteristics of the condition.[6][7]. As the ways in which gut microbiota connect with metabolic pathways, hormone regulation, and immune responses become more evident, a framework for comprehending the importance of gut health in PCOS management is being established. Certain gut bacteria are specifically linked to the metabolism of branched-chain amino acids, which can affect insulin sensitivity and androgen levels, thereby adding complexity to the clinical presentation of PCOS [8][9]. Potential controversies in this area of research include doubts about the reliability of findings due to limited diversity in study populations, as most studies have primarily focused on individuals of European descent, which may not reflect the global PCOS population [10]. Additionally, although probiotics and dietary interventions appear promising for enhancing gut health and reducing PCOS symptoms, their effectiveness and mechanisms need further exploration to develop standardized treatment methods[11][12]. Grasping t