DOI: https://doi.org/10.36347/sasjs.2025.v11i06.002

Pages: 668-673

Background: Neurofibromas are benign peripheral nerve sheath tumors commonly associated with Neurofibromatosis Type 1 (NF1), though sporadic forms also exist. Lesions located in the antecubital region present particular challenges due to the density of neurovascular structures. Case Presentation: We report the case of a 50-year-old male presenting with a painless, progressively enlarging mass in the right elbow crease. Magnetic resonance imaging and histopathological evaluation confirmed the diagnosis of a plexiform neurofibroma involving the median nerve. Complete surgical excision was achieved without postoperative complications. Conclusion: Plexiform neurofibromas of the antecubital fossa are rare. Given the anatomical complexity of the region, they require careful diagnostic assessment and meticulous surgical planning to minimize neurological morbidity and preserve upper limb function.