DOI: https://doi.org/10.36347/sasjm.2025.v11i07.005

Pages: 683-685

Introduction: Trisomy 13, a severe chromosomal anomaly with an incidence of 1/5000–1/20,000 live births, is characterized by multiple congenital malformations, including cleft lip and palate, renal anomalies, and polydactyly. Antenatal ultra- sound facilitates early diagnosis, guiding management decisions. Case Presentation: A 38-year-old primigravida’s fetus was diagnosed with tri-somy 13 at 13 weeks via trophoblast biopsy, presenting bilateral cleft lip and palate, right megaureter, bilateral hydronephrosis, hexadactyly, and suspected Dandy- Walker malformation. Medical termination was performed at 20 weeks + 5 days. Results: Comprehensive ultrasound and genetic evaluation confirmed the diagno- sis, supporting informed decision-making for termination due to poor prognosis. Conclusion: This case underscores the critical role of antenatal ultrasound in de-tecting trisomy 13 and the importance of multidisciplinary counseling for complex congenital anomalies.