DOI: https://doi.org/10.36347/sasjm.2025.v11i08.007

Pages: 776-780

When mental health issues coexist with seemingly unconnected physical conditions, the diagnosis process can become extremely complicated, necessitating a multidisciplinary approach and heightened clinical awareness. Mitochondrial neurogastrointestinal encephalopathy is an uncommon but significant example of a condition where mild neurological and gastrointestinal symptoms may appear and possibly conceal underlying metabolic abnormalities. With an emphasis on psychiatric, neurological and gastrointestinal symptoms that could complicate diagnosis, this featured review investigates how general practitioners (GPs) and multidisciplinary teams (MDTs) can identify atypical presentations of MNGIE. We emphasize the importance of general care in negotiating the intricacies of these uncommon multisystemic illnesses, as well as clinical hints and diagnostic techniques.