DOI: https://doi.org/10.36347/sjmcr.2025.v13i08.036

Pages: 1894-1899

Gliosarcoma is a rare aggressive variant of glioblastoma, classified as WHO grade IV a rare and aggressive variant of glioblastoma, affecting men between the ages of 50 and 60. It is characterized by a biphasic histological pattern combining glial and mesenchymal components. The pathogenesis remains debated. Prognosis remains poor, with median survival ranging from 8 to 17 months. Gliosarcoma remains a diagnostic and therapeutic challenge. Despite histological similarities with GBM, its distinct clinical behavior and metastatic potential warrant further investigation to improve management strategies and patient outcomes. This case study aimed to demonstrate the anatomopathology of gliosarcoma, and its aggressiveness.