DOI: https://doi.org/10.36347/sajp.2025.v14i09.001

Pages: 196-202

Antimicrobial resistance is a global health threat and human development. It requires urgent efforts across a range of sectors to achieve sustainable development goals. The World Health Association (WHO) has identified 'AMR', as one of the top 10 global public health threats facing humanity. The problem generates significant economic losses. In addition to death and disability, prolonged illness leads to longer hospital stays, require more expensive medicines and create financial hardship for those affected. The aim of current study is to summarise mechanisms of resistance of microorganisms to antibiotics and especially of antibiotic resistance in Mycobacterium bovis and Mycobacterium caprae; to present new strategies for overcoming drug resistance such as new targets from the bacterial genome as bacterial riboswitches and natural derivatives with antibacterial activity and potential to modify resistance.