DOI: https://doi.org/10.36347/sasjs.2025.v11i12.002

Pages: 1080-1083

Introduction: Intussusception is defined as the telescoping of one intestinal segment into the adjacent segment. It is rare in adults and most often secondary to an underlying cause, but the exact mechanism remains undefined. It is classified based on location and etiology. Malignant pathology is the most common, particularly for colonic intussusception. Lipoma is a rare cause of intussusception. Case Report: In this article, we report the rare case of a patient who presented with sigmoid intussusception due to a lipoma, treated by surgical resection. Discussion: Intestinal intussusception in adults is different from that in children, which is most often idiopathic. Malignant tumor pathology represents two-thirds of colonic intussusceptions. Colonic lipoma is a rare cause of intussusception; the diagnosis is established through CT scans and colonoscopy, but it is often difficult to differentiate it from cancer. This is why the case we present is interesting due to its location in the sigmoid colon, which is not common, and the diagnostic uncertainty poses a challenge for therapeutic management. Conclusion: The management of colonic intussusception in adults is not universally accepted; in cases of diagnostic uncertainty regarding the histological nature of the causal pathology, en bloc surgical resection without prior disinvagination seems to be the most appropriate approach given the high risk of malignancy.