DOI: https://doi.org/10.36347/sasjm.2025.v11i12.004

Pages: 1149-1153

Benign non-functioning adrenal incidentalomas (NFAI) represent the majority of adrenal masses incidentally discovered during imaging studies. Although traditionally considered hormonally inactive, several studies suggest their association with metabolic abnormalities, particularly metabolic syndrome and insulin resistance. The objective of our study is to evaluate the metabolic profile of patients with NFAI and to analyze the association between these lesions, metabolic syndrome, and insulin resistance. We conducted a descriptive cross-sectional study including 30 patients with NFAI, followed in the Department of Endocrinology, Diabetology and Nutrition at Mohammed VI University Hospital of Marrakech between October 2015 and December 2024. Out of 60 medical records concerning adrenal tumors during the study period (2015–2024), 31 cases of incidentalomas were identified, of which 30 were eligible. The mean age of patients was 56.2 years, with a female predominance (70%). The majority of lesions were unilateral non-functioning adenomas (70%). From a metabolic perspective, 30–36% of patients presented with metabolic syndrome, and 30% showed insulin resistance as evidenced by a HOMA-IR index > 2.4. Obesity (50%), hypertension (40%), and dyslipidemia (20%) were frequently associated. These findings confirm the close relationship between NFAI, metabolic syndrome, and insulin resistance, highlighting the importance of integrating metabolic approach in the management of NFAI.