DOI: https://doi.org/10.36347/sjmcr.2025.v13i12.009

Pages: 2939-2941

Malignant staphylococcal infection is a severe condition driven by the virulence of Staphylococcus aureus, potentially leading to serious systemic complications. Among these, cerebral septic emboli represent a rare but life-threatening entity. We report the case of a 50-year-old man admitted to the intensive care unit for septic shock due to S. aureus, complicated by multiple cerebral ischemic lesions resulting in prolonged coma. Brain MRI and blood cultures allowed rapid diagnosis. Antibiotic therapy tailored to microbiological results and adjusted to the patient's end-stage renal disease, combined with preventive anticoagulation and intensive care support, resulted in significant neurological improvement and successful extubation on day 12. This case highlights the importance of early and aggressive management in severe S. aureus bacteremia.