DOI: https://doi.org/10.36347/sjmcr.2025.v13i12.034

Pages: 3033-3036

Spindle cell neoplasms represent an heterogeneous group of both benign and malignant tumors. They rarely occur in the oral cavity, accounting for less than 1% of all oral tumors. Sarcomatoid squamous cell carcinoma (SSCC) also referred to as spindle cell carcinoma or Lane’s tumor is an uncommon and distinct biphasic malignant tumor that primarily affects the upper aerodigestive tract. This variant of squamous cell carcinoma features spindled or pleomorphic tumor cells that mimic true sarcoma but are of epithelial origin. Known for its aggressive behavior, SSCC has a high tendency for recurrence and metastasis, underscoring the need for accurate diagnosis. We report a case of SSCC, supported by immunohistochemical findings.