DOI: https://doi.org/10.36347/sasjm.2025.v11i12.015

Pages: 1226-1234

Background: Among women, breast cancer is the most frequent cancer and represents a major cause of death. Imaging for early detection is crucial in that it greatly contributes to prognosis and survival. Mammography is considered the reference procedure for both breast cancer screening and diagnosis,9 whereas ultrasound has a supportive function, especially in women with dense breasts or in cases of symptomatic patients. Nonetheless, the diagnostic yields of these modalities differ across patient populations and clinical settings. Objective: Herein, we compared the diagnostic performance of breast US and mammography for detecting and characterizing breast diseases, and explored the correlations with histopathological findings. Methods: Study Design: Cross-sectional diagnostic accuracy study on 84 symptomatic females who have had breast ultrasound and/or mammography. Imaging features were categorized according to the Breast Imaging Reporting and Data System (BI-RADS) and correlated with histopathological findings proved by means of fine-needle aspiration cytology, core needle biopsy, or excisional biopsy. Sensitivity, specificity, positive predictive value and negative predictive value as diagnostic performance parameters were calculated. Results: Ultrasonographic detection rate for breast masses was greater than mammography, and the sensitivity for malignant masses was slightly higher on mammography. Both modalities exhibited high specificity. The sensitivity and specificity for both identification of breast cancer and differentiation between malignant and benign lesions could be enhanced by combining ultrasound with mammography. Fibroadenoma was the most common benign lesion and malignancy accounted for more than one fourth of study population. Conclusion: It is useful to combine ultrasonography and mammography in the diagnosis of breast lesions. Together, they achieve greater diagnostic accuracy and better correlation with histology, justifying their use as screeni