DOI: https://doi.org/10.36347/sasjm.2025.v11i12.017

Pages: 1239-1241

Introduction: Trichofolliculoma (TF) is a rare, benign adnexal neoplasm originating from hair follicle germinative cells. Despite its characteristic clinicopathologic features, TF is frequently misdiagnosed due to its mimicry of other follicular lesions. Case Report: A 47-year-old female presented with an asymptomatic mass on the scalp. The lesion appeared as a flesh-colored, domeshaped, smooth nodule being the size of 5 mm in diameter, with a smooth surface, and located on the scalp. Shave excision was performed, and the diagnosis of fibrofolliculoma was confirmed finally through histological exam. Conclusion: Trichofolliculoma is rare, and generally diagnosed by histopathological exam after excision and biopsy. Awareness of its immunophenotype aids accurate distinction from other follicular neoplasms. Trichofolliculoma should be included in the differential diagnosis when a localized mass lesion arising in the scalp is encountered. Complete surgical excision is curative; recurrence is rare.