DOI: https://doi.org/10.36347/sjmcr.2026.v14i02.016

Pages: 245-247

This case highlights systemic vasculitis, an inflammatory condition that affects small blood vessels, presenting in two distinct forms: one linked to anti-neutrophil cytoplasmic antibodies (ANCA) and the other to anti-glomerular basement membrane antibodies (GBM). The study focuses on a 36-year-old patient with double positive vasculitis. Laboratory tests revealed the presence of both anti-glomerular basement membrane antibodies (anti-GBM) and anti-neutrophil cytoplasmic antibodies (anti-PR3). The renal biopsy confirmed extracapillary glomerulonephritis on proliferative glomerulonephritis, with C3 deposits and mild indications of chronicity. The patient's treatment included hemodialysis sessions, plasma exchanges, corticosteroid boluses, and cyclophosphamide after showing improvement with antibiotics. Considering the rarity and severity of this association, comprehensive clinical studies are crucial to improve therapeutic approaches and gain a deeper understanding of this intricate pathological condition.