DOI: https://doi.org/10.36347/sajp.2025.v14i09.006

Pages: 249-253

Ulcerative colitis is an idiopathic chronic relapsing–remitting inflammatory disorder that affects the colon and rectum. The present study was an attempt to investigate in-vivo intestinal anti-inflammatory activity by using the polyherbal plant extact which is combination of roots of Hemidesmus indicus and seeds of Centratherum anthelminticum. Inflammation was successfully produced by intra-rectal administration by using 4% glacial acetic acid in albino Wistar rats via intra rectal route for assessment of acute intestinal anti- inflammatory effect. Positive control animals were only treated with vehicle and simultaneously animals of other groups oral treatment with two doses (500mg/kg & 1000mg/kg b.w) and Prednisolone (2mg/kg b.w) Polyherbal Plant Extracts treated of animals significantly reduced in a colon score compared to positive control group of animals. Significant decrease in Myeloperoxidation, and Lipidperoxidation as compared to positive control group of animals. Polyherbal Plants Extracts treatment likely to be responsible for the observed significant intestinal anti-inflammatory effect via anti-oxidant mechanism.