DOI: https://doi.org/10.36347/sjavs.2026.v13i02.001

Pages: 32-39

Solenostemon monostachyus, SOM, has aroused overwhelming attention, in recent years. There is growing concern whether SOM expresses its effect via a particular phytoconstituent, a combination of fractions, or otherwise. This study investigated the effect of both the ethanol extract and alkaloid fraction of SOM on some antioxidant biomarkers. Twenty-five adult Wistar rats were randomly grouped into five batches (n=5). Group I (control) received rodent feeds and water; Group II had 200mg/kg body weight of ethanol extract of SOM; Group III (400mg/body weight of ethanol extract). While groups IV and V, respectively, received, 33mg and 66mg/kg body weight of SOM alkaloid fraction. Serum levels of Superoxide dismutase (SOD), malondialdehyde (MAD) and catalase (CAT) enzymes were evaluated. The results showed significant reduction of SOD and CAT activity while MOD levels were elevated by the effect of crude extract and alkaloid fraction. This suggests SOM’s potential in maintaining cellular integrity and preventing tissue damage via anti-oxidative activity and reducing liquid peroxidation.