DOI: https://doi.org/10.36347/sasjm.2026.v12i03.010

Pages: 206-208

Non-functioning pituitary adenomas (NFPAs) are common pituitary tumors characterized by the absence of clinical manifestations related to hormonal hypersecretion, often resulting in delayed diagnosis and presentation at an advanced stage. This cross-sectional study aimed to describe the demographic, clinical, radiological, and immunohistochemical characteristics of NFPAs managed between January 2018 and December 2024 at the Diabetology-Endocrinology Department of CHU Mohammed VI de Marrakech. Twenty-eight patients were included. Clinical, imaging, and histopathological data were retrospectively collected. Immunohistochemical analysis was performed using anti-LH, anti-FSH, and anti-GH antibodies to determine tumor subtype. The cohort showed a marked female predominance (71.4%), with a mean age of 40.7 years. Headache and decreased visual acuity were the most common presenting symptoms. Magnetic resonance imaging revealed a predominance of macroadenomas. Immunohistochemistry identified silent gonadotroph and silent somatotroph adenomas, while most tumors were classified as null cell or poorly differentiated adenomas. These findings highlight the importance of immunohistochemistry in accurately classifying NFPAs and identifying subtypes with potential aggressive behavior. An integrated clinical, radiological, and pathological approach is essential for optimal patient management and prognostic stratification.