DOI: https://doi.org/10.36347/sjams.2026.v14i03.011

Pages: 380-387

FOLLICLE stimulating hormone and testosterone both aid in the spermatozoa's ultimate development and guard the germ cell line from apoptosis. flat epididymis are characteristics of men who have azoospermia as a result of secondary testicular failure. Primary testicular failure reduces testosterone production, diminishes negative feedback inhibition, and increases gonadotropin production (hypergonadotropic hypogonadism). This study was carried out to assess the effect of ethanol of seed extract of Xylopia aethiopica on cadmium chloride induced toxicity on luteinizing and follicle stimulating hormones and testosterone in adult male wistar rats. Twenty (20) male albino wistar rats were used for this study. The animals were randomly divided into four groups with each containing four adult male wistar rats. Group 1 received distilled water and feed per day for 14 days, group 2 was treated with 2mg/body weight of Cadmium for 14 days, group 3 was treated with 2mg/body weight of Cadmium plus 50mg body weight of ethanol of seed extract of Xylopia aethiopica, group 4 was treated with 2mg/body weight of Cadmium plus 100mg/body weight of ethanol of seed extract of Xylopia aethiopica, group 5 was treated with 100mg/ body weight of of ethanol of seed extract of Xylopia aethiopica. The experiment lasted for 14 days. The rats were weighed before the experiment and after each week of administration. After 14 days of administration, the rats were sacrificed via chloroform inhalation and the testes harvested and fixed immediately in 10% buffered formalin, processed and stained with hematoxylin and eosin (H&E) staining method. Blood samples were collected were collected by cardiac puncture in EDTA bottle and plain bottles for analysis of serum follicle stimulating hormone, luteinizing hormone and testosterone. Data were expressed as Mean + standard error of the Mean (mean + SEM) and subjected to one-way analysis of variance (ANOVA). Significant difference between mean was assessed by D