DOI: https://doi.org/10.36347/sjmcr.2026.v14i03.065

Pages: 589-592

Kaposi Sarcoma is a vascular neoplasm associated with infection by Human Herpesvirus 8 [HHV-8]. The classical form usually occurs in elderly individuals and predominantly involves the skin of the lower extremities, whereas visceral involvement is uncommon compared with HIV-associated cases [1,2]. We report the case of an 89-year-old woman admitted for progressive angiomatous nodular lesions affecting both lower limbs. Dermatological examination revealed multiple violaceous macules, papules, plaques, and nodules associated with bilateral lower limb edema. Histopathological examination showed a dermal spindle-cell vascular proliferation with erythrocyte extravasation. Immunohistochemistry demonstrated strong positivity for HHV-8, confirming the diagnosis of Kaposi sarcoma. Imaging studies revealed peribronchovascular pulmonary micronodules with septal thickening as well as splenic and hepatic nodules suggesting systemic involvement. The patient was referred to oncology for systemic therapy with weekly low-dose paclitaxel. This case highlights an unusual presentation of classical Kaposi sarcoma with probable visceral involvement in an HIV-negative elderly patient.