DOI: https://doi.org/10.36347/sjmcr.2026.v14i04.039

Pages: 752-755

Central precocious puberty (CPP) associated with hypothalamic hamartoma (HH) is a rare but well-established cause of premature activation of the gonadotropic axis. We report the case of a 4 years and 3 months-old girl presenting with rapid onset of pubertal signs, associated with advanced bone age and elevated gonadotropin and oestradiol levels. Brain MRI confirmed the presence of a hypothalamic hamartoma. Treatment with GnRH agonists (triptorelin) led to regression of clinical signs and hormonal normalisation. This case highlights the importance of early diagnosis and multidisciplinary management to prevent complications, particularly reduced growth potential.