DOI: https://doi.org/10.36347/sjmcr.2026.v14i04.044

Pages: 773-776

Buschke–Löwenstein tumor [BLT], also known as giant condyloma acuminatum, is a rare sexually transmitted lesion associated with human papillomavirus [HPV] infection, most commonly low-risk genotypes 6 and 11. Although histologically benign, it is characterized by locally aggressive behavior, a high risk of recurrence, and possible malignant transformation into squamous cell carcinoma. We report the case of a 48-year-old man with chronic hepatitis C on direct-acting antiviral therapy, who presented with a slowly enlarging anoperineal mass evolving over two years. Clinical examination revealed a large exophytic verrucous cauliflower-like lesion measuring 9 × 7 cm, extending to the anal margin, associated with chronic maceration, malodorous discharge, and minimal contact bleeding. No inguinal lymphadenopathy or obvious anal canal involvement was noted on examination. The clinical presentation was highly suggestive of Buschke–Löwenstein tumor. Through this case, we highlight the clinicopathological features, diagnostic challenges, therapeutic principles, and prognostic implications of this uncommon entity.