DOI: https://doi.org/10.36347/sasjm.2026.v12i04.025

Pages: 374-376

This case report describes a 68-year-old woman presenting with fever and painful, hemorrhagic blisters localized to her palms and hands. Histopathological examination confirmed bullous pyoderma gangrenosum (PG), a rare neutrophilic dermatosis characterized by subepithelial bullae and dense neutrophilic infiltration. While bullous PG is frequently associated with underlying hematological malignancies, this patient responded rapidly to systemic corticosteroid therapy within 48 hours. This case emphasizes the clinical recognition of an extremely rare PG variant and the necessity of prompt immunosuppressive treatment to prevent further tissue destruction.