DOI: https://doi.org/10.36347/sasjm.2026.v12i05.001

Pages: 383-386

Background: Lissencephaly is a rare malformation of cortical development caused by abnormal neuronal migration, leading to severe neurological impairment from the neonatal period or early childhood. Objective: To report two pediatric cases of lissencephaly and to highlight their clinical and MRI characteristics in light of recent literature. Case Presentation: The first case involved a 3-year-old boy with type I lissencephaly associated with parieto-occipital band heterotopia (double cortex). The second case concerned a female neonate presenting with lissencephaly with pachygyria associated with diffuse leukoencephalopathy, suggesting a complex genetic and metabolic etiology. Conclusion: MRI remains the cornerstone for the diagnosis and characterization of lissencephaly. The association with white matter abnormalities or band heterotopia suggests syndromic and genetically heterogeneous forms, requiring multidisciplinary management.