DOI: https://doi.org/10.36347/sjmcr.2026.v14i05.023

Pages: 960-962

Kawasaki disease is an acute systemic vasculitis predominantly affecting children, while adult-onset cases remain rare and poorly recognized. This rarity often leads to diagnostic delay and increases the risk of cardiovascular complications. We report the case of a previously healthy 19-year-old man admitted for persistent high-grade fever unresponsive to antibiotics, associated with conjunctival injection, mucocutaneous involvement, and inflammatory biological markers. Extensive infectious and autoimmune investigations were negative. Based on clinical features and exclusion of alternative diagnoses, adult-onset Kawasaki disease was diagnosed. The patient was treated with intravenous immunoglobulins and aspirin, resulting in rapid clinical and biological improvement. Cardiac investigations showed no coronary artery involvement during follow-up. This case highlights the importance of considering Kawasaki disease in adults presenting with prolonged fever and mucocutaneous manifestations, as early recognition and treatment are essential to prevent potentially severe cardiac complications. Keywords: Adult-onset; Kawasaki disease; Prolonged fever; Vasculitis; Intravenous immunoglobulins; Coronary complications.