DOI: https://doi.org/10.36347/sjams.2026.v14i05.020

Pages: 765-772

Background: Acute febrile illness (AFI) is a common clinical condition characterized by sudden onset of fever without an identifiable source at initial evaluation. It is frequently encountered in tropical and subtropical regions and may result from viral, bacterial, or parasitic infections. Because many diseases present with similar symptoms, diagnosis is often challenging. Evaluating the clinical presentation and biochemical characteristics of AFI is essential for accurate diagnosis, timely treatment, and improved patient outcomes. Objectives: To assess demographic profile, clinical presentation, and biochemical characteristics of adult patients presenting with acute febrile illness at a tertiary care center. Methods: This cross-sectional observational study was conducted at Ibn Sina Diagnostic & Consultation Center, Uttara, Bangladesh from January to December 2018. A total of 256 adult patients presenting with acute febrile illness were included. Data were collected using structured questionnaires, clinical examinations, and laboratory investigations including complete blood count and biochemical tests. Statistical analysis was performed using SPSS version 21.0, presenting results as mean, standard deviation, frequencies, and percentages. Ethical approval and informed consent were obtained. Result: Among 256 patients, the mean age was 38.6 ± 12.4 years; 32.0% were 18–30 years and 58.6% were male. Fever duration was 4–7 days in 43.0%. Dehydration (25.8%) was the commonest clinical finding. Thrombocytopenia occurred in 35.9%, leukocytosis in 28.1%. Elevated CRP was found in 43.8%. Dengue fever (28.9%) was the leading cause. Most patients recovered completely (77.3%), while mortality was 0.8%. Conclusion: Acute febrile illness commonly affects young adults; dengue predominates, with thrombocytopenia and elevated CRP frequent, emphasizing importance of early diagnosis and management.