DOI: https://doi.org/10.36347/sasjm.2026.v12i05.024

Pages: 498-500

Lupus Erythematosus Profundus is a rare presentation and subset of erythematosus. Lupus erythematosus (LE) is termed as an autoimmune chronic condition which involves a spectrum of symptoms. It is a part of the connective tissue diseases. Its cutaneous form is termed as cutaneous lupus erythematosus (CLE). Prevalence of CLE is about 70 cases per 100,000 persons. The least common variety of CLE is lupus profundus (LP) only 5% of cases. Lupus profundus, although rare, must be kept in the differential diagnoses of ulcerated lesions. It may present as a localized entity or in association with systemic lupus erythematosus (SLE) or it may lead to SLE later in life. Early diagnosis based on histopathology and aggressive treatment is essential to prevent significant physical morbidity and progression to systemic involvement. We report a case of biopsy-proven lupus profundus in a 40-year-old female who presented with lesions on forearms. The lesions were appreciated on the both forearms. They had an erythematous base and edematous necrotizing centers. Patient was treated with methotrexate, hydroxychloroquine and steroids. It may present as a localized entity or in association with SLE or it may lead to SLE later in life.