DOI: https://doi.org/10.36347/sjams.2026.v14i05.030

Pages: 825-827

Background: Endoscopic ultrasound (EUS) is a key diagnostic modality for pancreaticobiliary diseases. However, patient symptoms at referral may help predict EUS findings and guide clinical decision-making. Objective: To analyze the relationship between presenting symptoms and final diagnoses in patients undergoing pancreaticobiliary EUS. Methods: We conducted a retrospective analysis of patients referred for pancreaticobiliary EUS. Recorded symptoms included abdominal pain, jaundice, weight loss, vomiting, and fever. Diagnoses were categorized as malignant lesions, benign lesions, inflammatory conditions, or non-diagnostic findings. Results: A total of 129 patients were included. Pain was the most frequent symptom (72%), followed by weight loss (43%), jaundice (36%), vomiting (16%), and fever (5%). Malignant lesions were diagnosed in 28 patients, while benign cystic lesions were identified in 5 cases, inflammatory or infectious conditions in 5 cases, and non-diagnostic sampling in 6 cases. Multivariate logistic regression analysis demonstrated that weight loss was independently associated with malignant pancreaticobiliary disease (OR = 19.88, 95% CI 5.11–77.29, p < 0.001). Conclusion: Symptom patterns may provide useful clinical information before EUS evaluation. In this cohort, weight loss was the only symptom independently associated with malignant pancreaticobiliary disease.