DOI: https://doi.org/10.36347/sasjm.2026.v12i05.038

Pages: 581-583

Background: Wernicke’s encephalopathy (WE) is an acute neuropsychiatric disorder caused by thiamine deficiency. Although classically associated with chronic alcohol use, it is increasingly recognized in non-alcoholic patients, particularly in the setting of gastrointestinal diseases. Objective: To describe the clinical characteristics, diagnostic findings, management, and short-term outcomes of WE in non-alcoholic patients hospitalized in a gastroenterology department. Methods: A retrospective study was conducted between 2023 and 2025, including patients with suspected WE. Diagnosis was based on the presence of at least two components of the classical triad in a compatible clinical context. Clinical, radiological, and therapeutic data were collected. Results: Seven patients were included, with a mean age of 27.3 years and a female predominance. Nystagmus, ataxia, and confusion were the most frequent manifestations. Brain MRI confirmed the diagnosis in only one case, while EEG was often normal. Most patients improved after intravenous thiamine, although persistent deficits were observed in some cases. Conclusion: WE should be suspected in non-alcoholic patients with gastrointestinal diseases and malnutrition. Early administration of intravenous thiamine remains essential to prevent irreversible neurological damage.