DOI: https://doi.org/10.36347/sjams.2026.v14i06.001

Pages: 890-893

Background: Transfusion-Dependent Thalassemia (TDT) remains a major health burden requiring lifelong management. Understanding the demographic profile and clinical characteristics of these patients is vital for improving healthcare delivery and outcomes. Objective: To describe the demographic and clinical characteristics of children with TDT, including age distribution, thalassemia types, and transfusion history. Methods: A cross-sectional study was conducted among 103 children with TDT aged 4 to 18 years. Data regarding age, thalassemia genotype (Hb E-β vs. β thalassemia), duration of disease, frequency of blood transfusions, and use of iron chelating agents were recorded and analyzed. Results: The study cohort consisted of 103 patients. Among those with endocrine complications, the mean age was 13.6±1.35 years. A higher proportion of clinical complications was observed in patients with Hb E-β thalassemia (57.9%) compared to β thalassemia major (42.1%). Data indicated that longer disease duration and higher transfusion requirements were common among the older pediatric age group. Furthermore, variations in the consistent use of iron chelating agents were observed across the demographic spectrum. Conclusion: The demographic profile of TDT patients suggests that complications increase with age and duration of the disease. Tailored management strategies based on thalassemia genotype and age-specific needs are recommended to improve the quality of life for these children.