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Scholars Academic Journal of Pharmacy | Volume-10 | Issue-01
The Effect of Different Concentration of Poloxamer 188 on Nanocrystalline Characteristics of Celery Herb Extract (Apium graveolens L.)
Henni Rosaini, Harrizul Rivai, Maria Dona Octavia, Elva Yulia Rosanti, Indra Makmur
Published: Jan. 11, 2021 | 140 121
DOI: 10.36347/sajp.2021.v10i01.001
Pages: 1-5
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Abstract
Celery (Apium graveolens L.) is a plant from the Apiaceae family which contains apigenin compounds that can be used as an antihypertensive drug. Apigenin contained in celery has low solubility in water. One method to increase solubility is to create a nanocrystalline system. This study aimed to see the effect of differences in the concentration of Poloxamer 188 on the characterization of nanocrystalline formation of celery herb extracts. The results of the Particle Size Analyzer (PSA) show that the particle size distribution of formula 1 the concentration of Poloxamer 188 40% with a grinding time of 6 hours is 1648.5 while for formula 2 the concentration of poloxamer 188 50% with a grinding time of 5 hours is 1049.6 and formula 3 the concentration of poloxamer 188 60% with a grinding time of 5 hours was 1483.2. The zeta potential value of each formula is -11.2, -12.5, and -8.9. The X-ray diffractogram analysis shows the formula still maintains its crystallinity, which is indicated by the formation of sharp peaks in each formula. The surface morphology analysis shows formulas 1, 2, and 3 with a magnification of 500 times look irregular and no longer visible differences between extract powders herbs celery and poloxamer 188.