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Scholars Academic Journal of Pharmacy | Volume-10 | Issue-01
Evaluation of Some Biochemical Parameters of Envenomed Oryctolagus cuniculus
Obou Constantin Okou, Jacques Auguste Alfred Bognan Ackah, Abba Pacôme Obouayeba, Djané Hamed, Allico Joseph Djaman
Published: Jan. 15, 2021 | 128 86
DOI: 10.36347/sajp.2021.v10i01.003
Pages: 13-18
The general objective of this study was to evaluate the action of Naja nigricollis venom on certain biochemical parameters of rabbits. To carry out this study, three batches of three rabbits were formed with two control batches and one experimental batch. Each control lot is composed of three rabbits (male or female) while the experimental lot is composed of two males and one female. Each rabbit from the control lots was collected separately from the red tube (dry tube) and transported to the laboratory for analysis. The rabbits from the experimental batch were also collected separately a few minutes after the injection of Naja nigricollis venom for analysis of biochemical parameters. However, prior to these experiments, an in vitro hemolysis test of Naja nigricollis venom was performed on whole blood to verify the hemolysing power of Naja nigricollis venom. The results of this study reveal that:- the venom of Naja nigricollis has a dose-dependent hemolysing power in vitro and in vivo;- with a few exceptions, the biochemical parameters of males are generally higher than those of females;- the venom of Naja nigricollis causes kidney failure and cardiovascular disease in some animals, promotes a risk of coronary death and diabetes in others, causes neuromuscular and cardiac signs due to dyskalemia in others, and finally, a hepatocellular damage or disturbance of bile flow, a heart problem and vitamin B6 deficiency in one type of animal. - the venom of Naja nigricollis is fatal.